Thirteen-year-old Meg Murry, her little brother Charles Wallace, and their friend Calvin are guided by unearthly strangers as they go on a journey through space and time to search for Meg's and Charles' scientist father who disappeared while experimenting with a new form of space travel.

Left alone by her Indian tribe when they decide to sail to the east, Karana, a young Indian girl, lives on a beautiful but isolated island off the coast of California, where she spends eighteen years, surviving through her enormous courage and self-reliance. Year after year she waits for the ship to return but it never does. Finally she realizes she must make a fateful choice: follow her people on her own or remain alone fo rthe rest of her life....