A city is hit by an epidemic of "white blindness" which spares no one. Authorities confine the blind to an empty mental hospital, but there the criminal element holds everyone captive, stealing food rations and raping women. There is one eyewitness to this nightmare who guides seven strangers-among them a boy with no mother, a girl with dark glasses, a dog of tears-through the barren streets, and the procession becomes as uncanny as the surroundings...

Lionel Essrog has always respected Frank Minna, who helped him out when he was young, and when Frank is found dead, Lionel and his friends, the Minna Men, scour the streets of Brooklyn in search of the killer.