In an attempt to find a cure after being diagnosed with Creutzfeldt-Jakob's (aka mad cow) disease, Cameron Smith, a disaffected sixteen-year-old boy, sets off on a road trip with a death-obsessed video gaming dwarf he meets in the hospital.

Writing poetry helps fifth-grader Harper Lee Morgan cope with her father's absence, being evicted, and having to skip school to care for her brother while their mother works, and things look even brighter after she befriends a mute girl and a kindly disabled woman.